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Ritalinic acid is a substituted phenethylamine and an inactive major metabolite of the stimulant methylphenidate, dexmethylphenidate and ethylphenidate. When administered orally, methylphenidate is extensively metabolized in the liver by hydrolysis of the ester yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1).
Etymologically, ritalinic acid shares its roots with Ritalin, a common brand name for methylphenidate.
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